![]() A total of 5 grams is usually sufficient.□ For emergent reversal of anticoagulation, there is only one dose & one route of vitamin K that should be used: 10 mg IV vitamin K.PO administration has slower absorption.IM administration may cause hematoma formation.Subcutaneous administration has erratic absorption.Other routes are inferior for emergent reversal:.An anaphylactoid reaction is rate-related, so the likelihood of a severe adverse reaction at this slow of a rate is really zero. If you're absolutely terrified about this reaction, then infuse the vitamin K incredibly slowly (e.g.Fear of this reaction should never be a barrier to giving intravenous vitamin K to patients who need it. ![]() However, anaphylactoid reactions are generally less severe and can be avoided by infusing a drug slowly. Anaphylactoid reactions can present similarly to anaphylactic reactions and may be treated similarly.
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